Detour: A Short History of DNA Sequencing Technologies

Let’s learn how DNA arrays, sequencing bacterial genomes, and Hyseq were discovered.

In 1988, Radoje Drmanac, Andrey Mirzabekov, and Edwin Southern simultaneously and independently proposed the futuristic and at the time completely implausible method of DNA arrays for DNA sequencing. None of these three biologists knew of the work of Euler, Hamilton, and de Bruijn; none could have possibly imagined that the implications of his own experimental research would eventually bring him face-to-face with these mathematical giants.

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