Peculiar Statistics of the Forward and Reverse Half-Strands
Get some insights about the different nucleotide frequencies on the reverse and forward half-strands.
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Frequency switch and the ori location
The figure given below (upper left) reveals a surprising pattern. We have partitioned the E. coli genome into 46 equally sized fragments of approximately 100,000 nucleotides, starting at the experimentally verified terminus of replication, and then computed the frequency of cytosine in each window. The first 23 fragments (starting from ...